Intl Journal of Nanomedicine - 2007 cipro

Ciprofl oxacin were evaluated for modulated delivery from the lungs in a healthy rabbit model. An aliphatic disulfi de crosslinker, cleavable by cysteine was used to form cross-links between nanosized liposomes to form the agglomerates. The blood levels of drug after pulmonary instillation of free Ciprofl oxacin, liposomal Ciprofl oxacin, and the agglomerated liposomes encapsulating Ciprofl oxacin were evaluated.